A Lady Named Baybie portrays the day-to-day lives of the Rev. Baybie Hoover, an ordained minister, and her long-time friend, Virginia Brown. Both are blind women who refuse to conform to the rigid rules imposed by society upon the so-called handicapped. Rejecting the suggestion that they weave baskets or make brooms in workshops for the blind, the elderly but energetic women are seen working the streets of New York, tin cups in hand, by singing their favorite gospel hymns.