A fantasy about the survival of the fittest, the film follows the adventures of one young survivor of cataclysm in a devasted world-especially lacking in women. Anxious to find a mate, he manufactures a small aircraft and manages to reach the remnants of a big city.

There he moves in with a sympathetic doctor in a medical clinic, which has been fortified against the persistent attacks of a brutish aggressor. Somewhere in the building there is a woman, apparently a mental patient, in whom the doctor has a personal interest, but before he can make any advances, complications set in.

The Last Combat doesn't contain a single line of dialogue - it appears that the unnamed cataclysm has affected the vocal chords of the survivors.